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光滑念珠菌腹膜炎并发持续性非卧床腹膜透析:口服5-氟胞嘧啶成功治疗

Torulopsis glabrata peritonitis complicating continuous ambulatory peritoneal dialysis: successful management with oral 5-fluorocytosine.

作者信息

Cecchin E, De Marchi S, Panarello G, Franceschin A, Chiaradia V, Santini G, Tesio F

出版信息

Am J Kidney Dis. 1984 Nov;4(3):280-4. doi: 10.1016/s0272-6386(84)80105-5.

Abstract

We report two cases of fungal peritonitis caused by Torulopsis glabrata, an uncommon opportunistic pathogen, in patients with end-stage renal disease receiving continuous ambulatory peritoneal dialysis (CAPD). The general clinical characteristic of T glabrata peritonitis was comparable to previously reported cases of Candida peritonitis. Although appropriate therapy of fungal peritonitis in patients undergoing CAPD still remains controversial, both for the drug of choice and for the dosage to be used, our study indicates that a 5-week course of oral 5-fluorocytosine (5-FC) may obviate the need to remove the peritoneal catheter during the management of peritonitis caused by susceptible strains of T glabrata.

摘要

我们报告了两例由光滑球拟酵母菌引起的真菌性腹膜炎病例,该菌是一种罕见的机会致病菌,发生于接受持续性非卧床腹膜透析(CAPD)的终末期肾病患者。光滑球拟酵母菌腹膜炎的一般临床特征与先前报道的念珠菌性腹膜炎病例相似。尽管对于接受CAPD的患者,真菌性腹膜炎的恰当治疗在选择药物和使用剂量方面仍存在争议,但我们的研究表明,对于由敏感光滑球拟酵母菌菌株引起的腹膜炎,口服5-氟胞嘧啶(5-FC)5周疗程可能无需在治疗期间拔除腹膜导管。

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