[Comparative pharmacokinetics and biologic availability of paracetamol as suppositories].

After a single dose administration of either 4 suppositories Dolarist -250 (a total of 1000 mg paracetamol, N-acetyl-p-aminophenol) or 4 suppositories of a reference drug registered according to AMG 1976 (a total of 800 mg paracetamol) in 6 healthy subjects, the serum concentrations of paracetamol were determined until 24 h post application. The main pharmacokinetic parameters and the relative bioavailability were calculated. The maximum concentrations of both drugs were similar, however, with Dolarist-250 the serum levels observed after 3, 4, 6 and 8 h were significantly higher. The invasion and elimination rate as well as the relative bioavailability showed no relevant differences.