Wellman P J, Watkins P A, Nation J R, Clark D E
Neurotoxicology. 1984 Summer;5(2):81-90.
The potential aversive qualities of dietary cadmium chloride (10, 100 mg/kg) or cobalt chloride (20, 100, 200 mg/kg) were evaluated in a conditioned saccharin aversion task. Male Long-Evans hooded rats (n = 42) were trained to drink tap water and ingest 10 grams of chow during daily 60 minute access tests. During the aversion-acquisition phase, a second bottle containing 0.1% sodium saccharin was introduced and the various metal-adulterated diets (10 grams, dose calculated as mg metal base/kg body weight) offered in place of plain chow. During extinction testing, all rats were fed the plain chow. Diets adulterated with cadmium (10 or 100 mg/kg) or cobalt (100, 200 mg/kg) induced marked conditioned saccharin aversions after 2-3 days of exposure and were found to be profoundly resistant to extinction. Both cadmium (100 mg/kg) and cobalt (100, 200 mg/kg) induced a corresponding suppression of intake of adulterated food and significant weight losses. The relation of these aversive effects to the influence of cadmium and cobalt on operant responding for food reward is discussed.
在一项条件性糖精厌恶任务中评估了膳食中氯化镉（10、100毫克/千克）或氯化钴（20、100、200毫克/千克）潜在的厌恶性。雄性长爪沙鼠（n = 42）在每日60分钟的进食测试中接受训练，饮用自来水并摄入10克食物。在厌恶获得阶段，引入第二个装有0.1%糖精钠的瓶子，并提供各种掺有金属的食物（10克，剂量按金属碱毫克/千克体重计算）以代替普通食物。在消退测试期间，所有大鼠都喂食普通食物。掺有镉（10或100毫克/千克）或钴（100、200毫克/千克）的食物在暴露2 - 3天后诱导出明显的条件性糖精厌恶，并且发现对消退具有高度抗性。镉（100毫克/千克）和钴（100、200毫克/千克）都相应地抑制了掺有金属食物的摄入量并导致显著体重减轻。讨论了这些厌恶性效应与镉和钴对食物奖励操作性反应影响之间的关系。
