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[内源性寡肽和脑特异性蛋白对大鼠攻击行为的影响]

[Effect of endogenous oligopeptides and brain-specific proteins on aggressive behavior in the rat].

作者信息

Rylov A L, Sherstnev V V

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1984 Sep-Oct;34(5):904-10.

PMID:6542282
Abstract

In experiments on non-bred males of white rats, the effect was studied on their aggressive behaviour of intraventricular injections of brain-specific proteins of S-100 group, gamma-globuline fraction from the serum of rabbits immunized by proteines S-100 (gamma S-100) and non-immunized rabbits (gamma-SNK) as well as of angiotensin, bradikinin and saline. S-100 lowered intermales aggressivity and that connected with pain, and had phasic inhibitory effects on rats emotional reactivity. gamma S-100 increased the aggressivity connected with pain, did not affect the intermales aggressivity and phasically raised (as well as gamma-SNK) the emotional reactivity. gamma-SNK, angiotensin and bradikinin did not change these kinds of aggressivity. None of the administered agents influenced the level of rats predetary aggressivity.

摘要

在对白鼠非繁殖雄性个体进行的实验中,研究了脑室内注射S - 100组脑特异性蛋白、经S - 100蛋白免疫的兔血清γ-球蛋白组分(γS - 100)、未免疫兔的γ-球蛋白组分(γ - SNK)以及血管紧张素、缓激肽和生理盐水对其攻击行为的影响。S - 100降低了雄性个体间与疼痛相关的攻击性,并对大鼠的情绪反应具有阶段性抑制作用。γS - 100增加了与疼痛相关的攻击性,不影响雄性个体间的攻击性,并阶段性地提高了(与γ - SNK一样)情绪反应。γ - SNK、血管紧张素和缓激肽未改变这些类型的攻击性。所施用的药剂均未影响大鼠的捕食性攻击水平。

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