Sornmani S, Schelp F P, Vivatanasesth P, Patihatakorn W, Impand P, Sitabutra P, Worasan P, Preuksaraj S
Arzneimittelforschung. 1984;34(9B):1231-4.
In a pilot control project of Opisthorchis viverrini in the village of Nong Wai Irrigation Area, Khon Kaen, Northeast Thailand, selected population based chemotherapy with a single dose of 40 mg/kg of praziquantel (2 - cyclohexylcarbonyl-1,2,3,6,7,11 b-hexahydro-4H-pyrazino [2,1-a]isoquinolin-4-one,EMBAY8440,Biltricide) was given to the stool positive cases once a year for a period of 3 years commencing May 1981. Two villages (pop 942) with a prevalence of 58.3% were used as tests villages and another one (pop. 442) with a prevalence of 55.1% served as control. The project programme integrated chemotherapy, sanitation improvement and health education, whilst only chemotherapy was applied in the control village. Among the 736 cases of all villages, 666 were treated in the first year and the parasitological cure rate after one month was 95.9%. Side effects of praziquantel were minor and were minimized by changing the time of drug intake from morning to after dinner. After one year the prevalence of opisthorchiasis was 36.8% in the test villages and 54.8% in the control village. The study on re-infection rate revealed that the average monthly incidence rate among the population in the test villages was 2.0% per month (range 1.1-5.0%) whereas it was 5.0% per month (range 1.9-10.3%) in the control village. In May 1982, second treatment was given again to the positive cases in the three villages with the same dose. The second year evaluation is in progress.
在泰国东北部孔敬府农外灌溉区村庄开展的一项肝吸虫病试点控制项目中，从1981年5月开始，连续3年每年对粪便检测呈阳性的病例采用单剂量40毫克/千克吡喹酮（2 - 环己基羰基-1,2,3,6,7,11b-六氢-4H-吡嗪并[2,1-a]异喹啉-4-酮，EMBAY8440，必奇）进行基于人群的化疗。选取两个患病率为58.3%的村庄（人口942人）作为试验村，另一个患病率为55.1%的村庄（人口442人）作为对照村。该项目计划整合了化疗、环境卫生改善和健康教育，而对照村仅采用化疗。在所有村庄的736例病例中，第一年有666例接受了治疗，一个月后的寄生虫学治愈率为95.9%。吡喹酮的副作用较小，通过将服药时间从早晨改为晚餐后而降至最低。一年后，试验村肝吸虫病的患病率为36.8%，对照村为54.8%。再感染率研究表明，试验村人群的平均月发病率为每月2.0%（范围为1.1 - 5.0%），而对照村为每月5.0%（范围为1.9 - 10.3%）。1982年5月，再次对三个村庄的阳性病例给予相同剂量的第二次治疗。第二年的评估正在进行中。
