泰国孔敬府农朗亚村吡喹酮治疗华支睾吸虫病的临床现场试验。

Clinical field trial of praziquantel in opisthorchiasis in Nong Rangya Village, Khon Kaen Province, Thailand.

作者信息

Viravan C, Bunnag D, Harinasuta T, Upatham S, Kurathong S, Viyanant V

出版信息

Southeast Asian J Trop Med Public Health. 1986 Mar;17(1):63-6.

Abstract

A clinical field trial of praziquantel was carried out in Nong Ranya Village, Amphoe Ban Phai, Khon Kaen Province, with a population of 309 individuals, and 94% prevalence rate of opisthorchiasis. A mass treatment was carried out using a single dose of praziquantel at 40 mg per kg body weight. Acceptance for treatment was 91%. Follow-up stool examinations performed on days 14 and 60 gave prevalence rates of 20.5% and 22.2% respectively. Side effects including dizziness, headache, abdominal discomfort, nausea, vomiting, diarrhoea, lassitude, arthralgia, sleepiness, cramps and hot sensation were the complaints from 80% of adults and 40% of children. All of these were mild and transient except in one adult female who had severe diarrhoea and required intravenous fluid infusion.

摘要

在孔敬府班派县农拉亚村进行了吡喹酮的临床现场试验，该村有309人，华支睾吸虫病患病率为94%。采用单剂量40毫克/千克体重的吡喹酮进行了群体治疗。治疗接受率为91%。在第14天和第60天进行的随访粪便检查显示，患病率分别为20.5%和22.2%。80%的成年人和40%的儿童出现了副作用，包括头晕、头痛、腹部不适、恶心、呕吐、腹泻、乏力、关节痛、嗜睡、抽筋和热感。除一名成年女性出现严重腹泻并需要静脉输液外，所有这些副作用均为轻度且短暂的。