Singh D N
Exp Pathol. 1984;26(2):77-84. doi: 10.1016/s0232-1513(84)80073-0.
The presence of lysosomes and lysosomal-like bodies in the myocardium of spontaneously hypertensive rats (SHRs) under the influence of 1% NaCl was studied. In SHRs, 2 weeks and older, there was an observable increase of lysosomes and lysosomal-like bodies in the myocardium when compared to the myocardium of age-matched controls. It is postulated that degradation is initiated by primary lysosomes and that mitochondria seem to be a prime target. The degradation process is also believed to be a relevant factor in cardiac hypertrophy of SHRs and that a high NaCl intake coupled with a sustained high blood pressure enhanced this process.
研究了在1%氯化钠影响下自发性高血压大鼠（SHRs）心肌中溶酶体和类溶酶体小体的存在情况。在2周龄及以上的SHRs中，与年龄匹配的对照组心肌相比，心肌中溶酶体和类溶酶体小体有明显增加。据推测，降解由初级溶酶体启动，线粒体似乎是主要靶点。降解过程也被认为是SHRs心脏肥大的一个相关因素，高盐摄入加上持续的高血压会加剧这一过程。
