鼻烟的致突变性：对煤矿工人可能的健康影响。

Mutagenicity of tobacco snuff: possible health implications for coal miners.

作者信息

Whong W Z, Ames R G, Ong T M

出版信息

J Toxicol Environ Health. 1984;14(4):491-6. doi: 10.1080/15287398409530600.

Abstract

Mutagenicity of tobacco snuff extracts was studied using the Ames Salmonella/microsome assay system. No mutagenic activity was found for tobacco snuff extracts without S9 activation. However, mutagenic substances were formed from tobacco snuff extracts in an acidic environment. The mutagenic substances induced predominantly frameshift mutations and were direct-acting mutagens. Mutagenic activity of tobacco snuff extracts was enhanced in the presence of coal-dust extracts at low pH. Since tobacco snuff has been used by some coal miners to substitute for cigarettes, a possible risk for gastric cancer induction among coal miners is proposed.

摘要

使用艾姆斯沙门氏菌/微粒体检测系统研究了鼻烟提取物的致突变性。未活化S9的鼻烟提取物未发现致突变活性。然而，在酸性环境中，鼻烟提取物会形成致突变物质。这些致突变物质主要诱导移码突变，并且是直接作用的诱变剂。在低pH值下，煤尘提取物存在时，鼻烟提取物的致突变活性增强。由于一些煤矿工人使用鼻烟替代香烟，因此提出了煤矿工人患胃癌的潜在风险。