5种化合物对鼠伤寒沙门氏菌TA98菌株中5种诱变复合混合物的比较抗诱变性

Comparative antimutagenicity of 5 compounds against 5 mutagenic complex mixtures in Salmonella typhimurium strain TA98.

作者信息

Ong T, Whong W Z, Stewart J D, Brockman H E

机构信息

Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888.

出版信息

Mutat Res. 1989 Jan;222(1):19-25. doi: 10.1016/0165-1218(89)90031-1.

DOI:10.1016/0165-1218(89)90031-1

PMID:2643031

Abstract

Using the Ames Salmonella/microsome assay, we compared the antimutagenic activities of chlorophyllin, retinol, beta-carotene, vitamin C, and vitamin E against solvent extracts of coal dust, diesel emission particles, airborne particles, fried beef, and tobacco snuff. The results show that chlorophyllin inhibited 69% of the mutagenic activity of tobacco snuff and over 90% of that of the other 4 complex mixtures. Retinol inhibited 29-48% of the mutagenic activity of all 5 complex mixtures. beta-Carotene, vitamin C, and vitamin E inhibited, if any, less than 39% of the activity of the complex mixtures studied. Vitamin C enhanced the mutagenicity of airborne particles. These results indicate that for these dietary and environmental complex mixtures chlorophyllin is a more effective antimutagen than retinol, beta-carotene, vitamin C, and vitamin E.

摘要

我们使用艾姆斯沙门氏菌/微粒体试验，比较了叶绿酸、视黄醇、β-胡萝卜素、维生素C和维生素E对煤尘、柴油排放颗粒、空气悬浮颗粒、煎牛肉和鼻烟的溶剂提取物的抗诱变活性。结果表明，叶绿酸抑制了鼻烟诱变活性的69%，以及其他4种复杂混合物诱变活性的90%以上。视黄醇抑制了所有5种复杂混合物诱变活性的29%-48%。β-胡萝卜素、维生素C和维生素E对所研究的复杂混合物活性的抑制作用（若有）小于39%。维生素C增强了空气悬浮颗粒的诱变性。这些结果表明，对于这些饮食和环境复杂混合物，叶绿酸是比视黄醇、β-胡萝卜素、维生素C和维生素E更有效的抗诱变剂。