Kulcsár A, Kulcsár-Gergely J, Weisz G, Udvardy M
Arzneimittelforschung. 1984;34(10):1301-5.
The effects of two oral progestogens, norethisterone and d-norgestrel, were studied on hepatic functions in CFY female rats. In healthy animals both progestogens inhibited cytochrome-P-450 dependent nonspecific mixed function monooxygenases. Serum bilirubin and cholylglycin RIA values were normal. Protein and glycogen content of the liver remained intact after norethisterone, d-norgestrel reduced glycogen. The pathologic values characteristic for chronic carbon-tetrachloride damage improved on a highly significant grade when these progestogens were simultaneously administered. The progestogens inhibited mixed function monooxygenases. We may presume that in this way they inhibited the formation of hepatotoxic trichloromethyl free radical and improved several liver functions.
研究了两种口服孕激素炔诺酮和左炔诺孕酮对CFY雌性大鼠肝功能的影响。在健康动物中，两种孕激素均抑制细胞色素P-450依赖性非特异性混合功能单加氧酶。血清胆红素和胆酰甘氨酸放射免疫分析值正常。炔诺酮处理后肝脏的蛋白质和糖原含量保持完整，左炔诺孕酮使糖原减少。当同时给予这些孕激素时，慢性四氯化碳损伤的病理值有极显著改善。孕激素抑制混合功能单加氧酶。我们可以推测，它们通过这种方式抑制了肝毒性三氯甲基自由基的形成，并改善了多项肝功能。
