Wolf J P, Zafrani B, Salmon R J, Durand J C, Pilleron J P
J Gynecol Obstet Biol Reprod (Paris). 1984;13(6):657-61.
Since angiosarcoma of the breast was first reported in 1907 fewer than one hundred cases have been reported. They are primary malignant vascular mesenchymal tumors occurring in young females. Their prognosis is very bad. We report here six new cases treated at the Institut Curie between 1972-1983. The mean age was 33, range 27-40. One tumor was a low grade one and the five others of breast, were high grade tumors. We carried out four amputations three associated with radiotherapy and/or chemotherapy and the fourth one did not received adjuvant treatment. In the two others cases the diagnosis was made when the patients were already suffering from polymetastatic disease. The mean survival was 17 months, the range 5-44 months. Recent reviews of the pathologic material made it possible to differentiate three grades in these tumors. The prognosis was correlated to the degree of differentiation. Recently hormonal receptors have been described in soft tissue sarcomas. The value of levels of these receptors in breast angiosarcoma Is discussed.
自1907年首次报道乳腺血管肉瘤以来，报道的病例不足100例。它们是发生在年轻女性中的原发性恶性血管间质肿瘤。其预后非常差。我们在此报告1972年至1983年间在居里研究所治疗的6例新病例。平均年龄为33岁，范围在27至40岁之间。1例肿瘤为低级别肿瘤，另外5例乳腺肿瘤为高级别肿瘤。我们进行了4例截肢手术，其中3例联合放疗和/或化疗，第4例未接受辅助治疗。在另外2例病例中，诊断时患者已患有多灶转移疾病。平均生存期为17个月，范围为5至44个月。最近对病理材料的回顾使得在这些肿瘤中区分出三个级别成为可能。预后与分化程度相关。最近在软组织肉瘤中描述了激素受体。本文讨论了这些受体水平在乳腺血管肉瘤中的价值。
