Johnson B L, Mason R W
Neurotoxicology. 1984 Fall;5(3):1-22.
A review of public health regulations pertaining to lead exposure is the subject of this paper. Although lead had been used for centuries in the fabrication of a host of products, it was not until the mid-nineteenth century that the clinical pattern of lead poisoning was described in the medical literature. With this recognition gradually came government health regulations designed to limit human exposure to lead from occupational and environmental sources. The British, in particular, developed during the period 1890 to 1920 comprehensive rules and regulations pertaining to occupational lead exposures. The development and imposition of U.S. health regulations occurred later in the twentieth century; federal regulations not generally appearing until the 1970's. At present, several U.S. government agencies have promulgated regulations intended to prevent lead poisoning from paint; limit lead in ambient air, drinking water, workplace environments and consumer products; and reduce lead in fuels and fuel additives used in motor vehicles. These regulations are reviewed in terms of their extent of coverage. There is evidence, in some instances indirect in nature, that human exposure to lead in U.S. populations has been reduced, though comprehensive data are lacking. The Centers for Disease Control has reported that the mean blood lead level in the U.S. has decreased 36%, paralleling a reduction in the lead content of gasoline. For occupational lead exposure, comprehensive morbidity data do not exist, but an evaluation of NIOSH health hazard evaluations (HHE's) specific to lead show a gradual reduction since 1977 in the percentage of HHE's for which airborne lead exceeded 0.20 mg/m3, which at one time had been the federal standard for occupational lead exposure, prior to reduction of the U.S. standard to 0.05 mg/m3.
本文的主题是对与铅暴露相关的公共卫生法规进行综述。尽管铅在众多产品制造中已使用了数百年,但直到19世纪中叶,医学文献中才描述了铅中毒的临床症状。随着这一认识的逐渐形成,政府开始制定卫生法规,旨在限制人类从职业和环境来源接触铅。特别是英国,在1890年至1920年期间制定了与职业铅暴露相关的全面规章制度。美国卫生法规的制定和实施则发生在20世纪后期;直到20世纪70年代,联邦法规才普遍出现。目前,美国几个政府机构已颁布法规,旨在预防油漆导致的铅中毒;限制环境空气中、饮用水、工作场所环境和消费品中的铅含量;以及减少机动车使用的燃料和燃料添加剂中的铅含量。本文将根据这些法规的覆盖范围进行综述。有证据表明,在美国人群中,尽管缺乏全面数据,但在某些情况下,这种证据本质上是间接的,人类对铅的接触已有所减少。疾病控制中心报告称,美国的平均血铅水平已下降36%,这与汽油中铅含量的下降情况平行。对于职业铅暴露,不存在全面的发病率数据,但对美国国家职业安全与健康研究所(NIOSH)针对铅的健康危害评估(HHE)的评估显示,自1977年以来,空气传播铅含量超过0.20毫克/立方米(这曾是美国职业铅暴露的联邦标准,之后美国标准降至0.05毫克/立方米)的HHE百分比逐渐下降。