Goldstein G W
Neurotoxicology. 1984 Fall;5(3):167-75.
Like nutrients and waste products, toxic metals enter and leave the brain by passing through the endothelial cells of brain capillaries. In contrast to most systemic organs, the endothelial cells of the brain microvasculature are sealed together by tight junctions. The result is a blood-brain barrier produced by a continuous layer of endothelial cells. Since heavy metals most likely pass through these cells to enter the brain, it is not surprising that the metals may accumulate within and injure the capillary cells. This review will consider some of the features that distinguish endothelial cells in the brain from those in systemic organs. Special consideration will be given to processes shown in the Figure which may influence the transport and toxicity of inorganic lead.
与营养物质和代谢废物一样，有毒金属通过脑毛细血管的内皮细胞进出大脑。与大多数全身器官不同，脑微血管的内皮细胞通过紧密连接密封在一起。结果是形成了由连续的内皮细胞层构成的血脑屏障。由于重金属很可能通过这些细胞进入大脑，因此这些金属可能在毛细血管细胞内蓄积并造成损伤也就不足为奇了。本综述将探讨一些区分脑内皮细胞与全身器官内皮细胞的特征。将特别关注图中所示的可能影响无机铅转运和毒性的过程。
