Lê A D, Khanna J M, Kalant H
Alcohol. 1984 Nov-Dec;1(6):447-51. doi: 10.1016/0741-8329(84)90020-x.
The development of ethanol tolerance as a function of daily treatment dosage was examined on two different test systems. Tolerance to the motor-impairment effect of ethanol, as measured by the tilting-plane test, failed to develop after daily administration of 1-3 g/kg, but developed to equal degrees after 4 or 5 g/kg daily. On the other hand, daily treatment with 2, 4 or 6 g/kg all produced significant tolerance to the hypothermic effect, and the extent of tolerance was proportional to the treatment dosage. Twenty-four hours after the termination of ethanol treatment, there was a significant hypothermia in the group treated with 6 g/kg, and at 32 hr hyperthermia occurred in both the 4 and 6 g/kg groups. These results indicate that treatment dosage is an important determinant of the extent of ethanol tolerance and physical dependence, but that the relationship is complex and varies with the test system used.
在两个不同的测试系统上研究了乙醇耐受性随每日治疗剂量的变化情况。通过倾斜平面试验测量，每日给予1 - 3克/千克乙醇后，对乙醇运动损伤效应的耐受性未形成，但每日给予4或5克/千克乙醇后，耐受性以相同程度形成。另一方面，每日用2、4或6克/千克乙醇治疗均产生了对体温过低效应的显著耐受性，且耐受程度与治疗剂量成正比。乙醇治疗终止24小时后，给予6克/千克乙醇的组出现显著体温过低，4和6克/千克组在32小时时均出现体温过高。这些结果表明，治疗剂量是乙醇耐受性和身体依赖性程度的重要决定因素，但这种关系很复杂，且因所使用的测试系统而异。
