Scutellari P N, Orzincolo C, Cervi P M, Tilotta F
Radiol Med. 1984 Nov;70(11):837-44.
Radiographs of the hand of 53 patients with diffuse idiopathic skeletal hyperostosis (DISH) were compared with 20 acromegalic subjects and 100 matched controls. Bone qualitative changes, characteristic of DISH, include: (1) arrow-heading of the distal phalangeal tufts; (2) enthesopathy of the proximal phalanges; (3) enlarged sesamoid bones; (4) hook-like exostoses at the metacarpophalangeal heads; (5) cortical thickness of diaphyseal tubular bones. Therefore, the hand in this disease appears as a "robust" form, particularly in males, resembling acromegalic pattern, but in this disease, the hand is much more coarse (so called squared hand), especially because of the soft tissue involvement and articular cartilaginous hypertrophy. Only enthesopathy seems to be the most characteristic and peculiar finding of the disease. Quantitative bone change measurements have demonstrated in DISH that metacarpal and Exton Smith indices differ statistically toward the controls. The hand is wider, but in males bone mass may result the same and in female is shortly reduced. Soft tissue alterations, compared with the controls, are not significant. On the contrary, in acromegaly there is a significant statistical difference in all the quantitative measurements of both the skeletal and soft tissue lesions, compared with the controls and patients affected by DISH.
对53例弥漫性特发性骨肥厚(DISH)患者的手部X光片与20例肢端肥大症患者及100例匹配的对照者进行了比较。DISH的骨质定性改变包括:(1)远端指骨粗隆呈箭头状;(2)近端指骨附着点病;(3)籽骨增大;(4)掌指关节头部出现钩状骨赘;(5)骨干管状骨的皮质厚度。因此,该病患者的手部呈现出一种“粗壮”的形态,在男性中尤为明显,类似于肢端肥大症的表现,但在本病中,手部更为粗糙(所谓的方手),特别是由于软组织受累和关节软骨肥大。似乎只有附着点病是该病最具特征性和独特性的表现。DISH的定量骨改变测量结果显示,掌骨和埃克斯顿·史密斯指数与对照组相比有统计学差异。手部更宽,但男性的骨量可能相同,女性则略有减少。与对照组相比,软组织改变不显著。相反,与对照组和DISH患者相比,肢端肥大症在骨骼和软组织病变的所有定量测量中均有显著的统计学差异。