Brühl W, Adlung J, Marquardt R, Grazikowske H
Z Kardiol. 1978 Apr;67(4):265-7.
10 healthy probands were given on several subsequent days by intravenous infusion lasting 20' only orciprenalin and dopamine in therapeutic doses of 0.1 mg/kg bodyweight and 0.5 mg, respectively. In all cases application of orciprenalin resulted in a significant rise of glucose, insuline, lactate and free fatty acids. By contrast, no such changes were observed after infusion of dopamine. This suggests that a rise of free fatty acids in the serum may be important for the occurrence of cardiac arrythmia.
10名健康受试者在随后的几天里，仅通过持续20分钟的静脉输注，分别给予治疗剂量为0.1毫克/千克体重的奥西那林和0.5毫克的多巴胺。在所有情况下，应用奥西那林都会导致葡萄糖、胰岛素、乳酸和游离脂肪酸显著升高。相比之下，输注多巴胺后未观察到此类变化。这表明血清中游离脂肪酸的升高可能对心律失常的发生很重要。
