Spohr U, Hengen N, Harenberg J, Walter E, Augustin J, Comberg H U, Mörl H, Weber E
MMW Munch Med Wochenschr. 1980 Feb 20;122 Suppl 1:25-32.
The effects after smoking cigarettes with different nicotine content (1.5 mg and 0.08 mg nicotine/cigarette) were investigated in 6 healthy habitual smokers. Carboxyhemoglobin (COHb) and plasma nicotine levels were determined at the same time as circulatory parameters, heart rate and blood pressure together with metabolic parameters like blood sugar, lactate, free fatty acids and plasma dopamine-beta-hydroxylase (DBH) and plasma cortisol. With the exception of COHb the parameters investigated were shown to be dependent on the nicotine levels. For blood pressure, heart rate and lactate the peaks appeared simultaneously with the maximum nicotine levels, whereas for DBH, cortisol, blood sugar and the free fatty acids there was a delayed reaction in comparison with the nicotine levels. The parameters investigated are not affected by COHb with levels up to 5.6 +/- 0.5%. These results show that after cigarette smoking, nicotine causes considerable changes in the circulation and metabolism.
对6名健康的习惯性吸烟者研究了吸食不同尼古丁含量（每支香烟含1.5毫克和0.08毫克尼古丁）香烟后的影响。同时测定了碳氧血红蛋白（COHb）和血浆尼古丁水平以及循环参数、心率和血压，还有代谢参数如血糖、乳酸、游离脂肪酸、血浆多巴胺-β-羟化酶（DBH）和血浆皮质醇。除了COHb外，所研究的参数显示出依赖于尼古丁水平。对于血压、心率和乳酸，峰值与最大尼古丁水平同时出现，而对于DBH、皮质醇、血糖和游离脂肪酸，与尼古丁水平相比有延迟反应。所研究的参数在COHb水平高达5.6±0.5%时不受影响。这些结果表明，吸烟后，尼古丁会引起循环和代谢的显著变化。
