Peters U, Kalman S M
Z Kardiol. 1978 May;67(5):342-5.
Several methods for the determination of dihydrometabolites of digoxin are described. Dihydrometabolites of digoxin are essentially inactive. They are the most important group of metabolites of digoxin. Seven (7) percent of a group of in-patients excreted more than 35% of these metabolites. The average was 13%, with respect to total extractable digoxin and metabolites in urine. In blood up to 40%, and in urine up to 52% dihydrogenated metabolites were found. The main metabolite was dihydrodigoxin, but the hydrolytic metabolites of digoxin exist also in reduced form. Neither the dose of digoxin, impaired renal function, nor an increased body content of digoxin seems to affect the rate of formation of these dihydrometabolites.
本文描述了几种测定地高辛二氢代谢物的方法。地高辛二氢代谢物基本无活性。它们是地高辛最重要的代谢物组。一组住院患者中有7%排泄出超过35%的这些代谢物。相对于尿液中可提取的总地高辛和代谢物，平均值为13%。在血液中发现高达40%的二氢代谢物，在尿液中高达52%。主要代谢物是二氢地高辛，但地高辛的水解代谢物也以还原形式存在。地高辛的剂量、肾功能损害以及地高辛体内含量增加似乎均不影响这些二氢代谢物的形成速率。
