Matsuura J, Chiu D, Jacobs P A, Szulman A E
Genet Epidemiol. 1984;1(3):271-84. doi: 10.1002/gepi.1370010306.
An analysis of hydatidiform moles occurring in Hawaii over a 14-year period (1968-1981) was undertaken. The pathology of all 278 reported molar pregnancies was reviewed and showed 69.4% to be complete, 24.5% to be partial, and 6.1% to be nonmolar. A case-control epidemiological investigation of the complete moles showed maternal age and race to be important, moles being significantly more prevalent in women under 20 and over 40 yr of age and also in women of Japanese, Filipino, and other Oriental ancestry. However no difference was seen in the prevalence of moles between Oriental women born in the Orient and those born and raised in Hawaii. No significant difference was found in paternal age, paternal race, socioeconomic status, or reproductive history, suggesting that these factors do not play an important role in the etiology of complete hydatidiform mole. Incidence rates for complete moles were calculated taking age and race into consideration and ranged from a high of 1 in 150 to a low of 1 in 2,000 naturally terminating pregnancies.
对1968年至1981年这14年间发生在夏威夷的葡萄胎进行了分析。对所有278例报告的葡萄胎妊娠病例的病理进行了复查，结果显示完全性葡萄胎占69.4%，部分性葡萄胎占24.5%，非葡萄胎占6.1%。对完全性葡萄胎进行的病例对照流行病学调查显示，母亲年龄和种族很重要，葡萄胎在20岁以下和40岁以上的女性以及日本、菲律宾和其他东方血统的女性中明显更为普遍。然而，在东方出生的东方女性与在夏威夷出生和长大的东方女性之间，葡萄胎的患病率没有差异。在父亲年龄、父亲种族、社会经济地位或生育史方面未发现显著差异，这表明这些因素在完全性葡萄胎的病因中不发挥重要作用。考虑到年龄和种族，计算出完全性葡萄胎的发病率，在自然终止妊娠中，发病率从每150例中的1例高到每2000例中的1例低不等。
