通过琼脂糖-聚巯基微球珠进行血液灌流体外去除汞。

Extracorporeal removal of mercury by hemoperfusion through agarose-polymercaptal microsphere beads.

作者信息

Margel S, Marcus L, Mashiah A, Savin H, Dalit M

出版信息

J Biomed Mater Res. 1984 Jul-Aug;18(6):617-29. doi: 10.1002/jbm.820180604.

DOI:10.1002/jbm.820180604

Abstract

Uniform agarose-polymercaptal microsphere beads (APMMB) of 1.0-mm diameter were prepared by encapsulating thousands of polymercaptal microspheres of 0.8-micron average diameter within an agarose matrix. Those beads show a high avidity and affinity for mercury and readily remove mercury compounds bound to serum proteins. In vivo detoxification trials in dosed rabbits and dogs showed the effectiveness of the APMMB for removal of mercury compounds by hemoperfusion. The rate for mercury removal is enhanced by addition of cysteine. The biocompatibility of the APMMB, measured by the depletion of the formed elements and various soluble components of the blood, is also demonstrated.

摘要

通过将数千个平均直径为0.8微米的聚硫醇微球包裹在琼脂糖基质中，制备出直径为1.0毫米的均匀琼脂糖-聚硫醇微球珠（APMMB）。这些珠子对汞具有高亲和力，能轻易去除与血清蛋白结合的汞化合物。在给药的兔子和狗身上进行的体内解毒试验表明，APMMB通过血液灌流去除汞化合物的有效性。添加半胱氨酸可提高汞的去除率。还证明了通过血液中血细胞成分和各种可溶性成分的消耗来衡量的APMMB的生物相容性。

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