Keller J C, Marshall G W, Kaminski E J
J Biomed Mater Res. 1984 Sep;18(7):829-44. doi: 10.1002/jbm.820180713.
The peritoneal cavity of the rat was used as an implantation site in order to study the quantitative, cellular response and the qualitative, histopathological response to three metals (Ag, Sn, Cu). The effects of the metals on the cells were correlated with the cellular concentrations of the metal as determined by chemical analysis. Small variations in the cell population and a minimal foreign body reaction was observed with an implanted control material (silicone polymer). Large increases in the number of cells and an intense foreign body reaction was observed with Cu implants. Decreases in the number of cells were seen with Sn and Ag implants, but only Sn elicited a foreign body reaction. Implantation of Ag failed to elicit a foreign body reaction. Significant concentrations of all three metals were detected in the retrieved cells.
为了研究大鼠对三种金属（银、锡、铜）的定量细胞反应和定性组织病理学反应，将大鼠的腹膜腔用作植入部位。通过化学分析确定的金属细胞浓度与金属对细胞的影响相关。植入对照材料（硅酮聚合物）时观察到细胞群体的微小变化和最小的异物反应。铜植入物导致细胞数量大幅增加和强烈的异物反应。锡和银植入物使细胞数量减少，但只有锡引发了异物反应。银植入未引发异物反应。在回收的细胞中检测到所有三种金属的显著浓度。
