Tsai J F, Tsai J H, Chang W Y
Department of Internal Medicine, Kaohsiung Medical College, Taiwan.
Gastroenterol Jpn. 1990 Jun;25(3):388-93. doi: 10.1007/BF02779456.
Circulating immune complexes (CIC), complement and alpha-fetoprotein (AFP) were detected in 93 hepatitis B surface antigen (HBsAg)-positive patients with hepatocellular carcinoma (HCC), 16 patients with liver cirrhosis (LC) and 54 healthy controls. The CIC and complements were significantly higher in HCC patients than in LC patients. The complement and polyethylene glycol(PEG)-CIC in HCC patients with LC were higher than those in LC only (P less than 0.0001). The complement levels in LC patients were significantly lower than in controls. There was no difference in C3 and C4 between HCC patients and controls, while the C3 proactivator was higher in HCC patients (P less than 0.02). The C1q-CIC was higher in HCC and LC patients when compared to controls (P less than 0.0001). In patients with HCC, there was no difference in the CIC and complement levels between patients with cirrhosis and those without. There were inverse correlations between C1q-CIC and C3 (P less than 0.05), C1q-CIC and C4 (P less than 0.04). The mean level of 3% PEG-CIC and C1q-CIC increased significantly as AFP elevated, but decreased as AFP was higher than 1599 ng/ml (P less than 0.05). These results imply that CIC increase with tumor growth but further tumor burden may result in a fall in CIC, there was a shifting of CIC from complement-fixing to non-complement-fixing as AFP increased gradually.
在93例乙型肝炎表面抗原（HBsAg）阳性的肝细胞癌（HCC）患者、16例肝硬化（LC）患者和54名健康对照者中检测了循环免疫复合物（CIC）、补体和甲胎蛋白（AFP）。HCC患者的CIC和补体水平显著高于LC患者。合并LC的HCC患者的补体和聚乙二醇（PEG）-CIC水平高于单纯LC患者（P<0.0001）。LC患者的补体水平显著低于对照组。HCC患者与对照组的C3和C4无差异，而HCC患者的C3前活化剂较高（P<0.02）。与对照组相比，HCC和LC患者的C1q-CIC较高（P<0.0001）。在HCC患者中，有肝硬化和无肝硬化患者的CIC和补体水平无差异。C1q-CIC与C3之间呈负相关（P<0.05），C1q-CIC与C4之间呈负相关（P<0.04）。随着AFP升高，3%PEG-CIC和C1q-CIC的平均水平显著升高，但当AFP高于1599 ng/ml时则降低（P<0.05）。这些结果表明，CIC随肿瘤生长而增加，但进一步的肿瘤负荷可能导致CIC下降，随着AFP逐渐升高，CIC从补体结合型向非补体结合型转变。
