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[防御性条件反射形成与稳定过程中大脑乙酰胆碱酯酶活性的动态变化]

[Dynamics of acetylcholinesterase activity in the brain during elaboration and stabilization of defensive conditioned reflexes].

作者信息

Dish T N

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1978 Mar-Apr;28(2):322-5.

PMID:654572
Abstract

Electro-defensive condtioned reflexes (CR) to light were elaborated in rats in Y-maze in one experimental session and their training was continued during subsequent 20 sessions. Immediately after CR elaboration or the 20th session of its training, AChE activity in the motor and visual cortex and the hippocampus decreased, increasing again in 24 hours. Animals used as active control which received non-paired photic and electric stimuli, exhibited opposite changes of AChE activity.

摘要

在一个实验环节中,在Y型迷宫中对大鼠建立了对光的电防御条件反射(CR),并在随后的20个环节中持续进行训练。在建立CR后或训练的第20个环节后,运动皮层、视觉皮层和海马体中的乙酰胆碱酯酶(AChE)活性立即下降,并在24小时后再次升高。用作主动对照的动物接受非配对的光刺激和电刺激,其AChE活性呈现相反的变化。

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