Lew G M, Washko K, Quay W B
J Pineal Res. 1984;1(1):61-8. doi: 10.1111/j.1600-079x.1984.tb00195.x.
An ultrastructural stereological analysis was made of the nucleus in pinealocytes of 28 male Fischer rats sampled at seven times in a light:dark 12:12 photoperiod cycle. Comparisons of the data from the seven times, in relation to daily means, showed variations in mean nuclear cross-sectional surface area of +/- 16%, and in mean nuclear perimeter of +/- 10%. Peaks in both nuclear dimensions occurred at the middle of the light period and were coincident with the presence of elaborate nuclear configurations and deep indentations. At 2330 and 0430 (1 and 6 h after lights off) nuclear folding was generally less complex. Mitochondria were found in close association with the nuclear folds. Forty percent of nucleoli were marginated at all of the sampling times, except at 1130 (1 h after lights on) and at 2330 (1 h after lights off), when 50% and 35%, respectively, were marginated.
对28只雄性Fischer大鼠松果体细胞中的细胞核进行了超微结构立体分析，这些大鼠在12:12光暗周期的光照期内分7次取样。将这7次的数据与每日平均值进行比较，结果显示平均核横截面积变化为±16%，平均核周长变化为±10%。两个核维度的峰值出现在光照期的中间，且与精细的核结构和深陷痕的存在相一致。在23:30和04:30（熄灯后1小时和6小时），核折叠通常不太复杂。发现线粒体与核褶皱紧密相关。除了在11:30（开灯后1小时）和23:30（熄灯后1小时）分别有50%和35%的核仁边缘化外，在所有取样时间，40%的核仁处于边缘化状态。
