苯二氮䓬类耐受性的发展。II. 巴氯芬对大鼠在对硝西泮和奥沙西泮镇静作用产生耐受性期间活动的影响。
Development of tolerance to benzodiazepines. II. Baclofen effect on the activity of rats during tolerance to the sedative action of nitrazepam and oxazepam.
作者信息
Chodera A, Cenajek D, Chodera R, Nowakowska E, Szczawińska K
出版信息
Acta Physiol Pol. 1984 Jul-Aug;35(4):301-9.
PMID:6545924
Abstract
It was demonstrated that baclofen, a GABA-ergic agent, exerted a sedative effect in rats with tolerance to the sedative action of oxazepam and nitrazepam induced by administration of these drugs during several weeks. After one dose baclofen alone reduced the motor activity of rats without potentiating the effects of benzodiazepines. During long-term administration of baclofen tolerance developed also to its sedative action.
摘要
已证实，γ-氨基丁酸能药物巴氯芬对因连续数周服用奥沙西泮和硝西泮而产生镇静耐受的大鼠具有镇静作用。单独给予一剂巴氯芬可降低大鼠的运动活性，而不会增强苯二氮䓬类药物的作用。在长期给予巴氯芬的过程中，其镇静作用也会产生耐受性。
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