苯二氮䓬类药物耐受性的发展。I. 硝西泮长期给药过程中中枢神经系统神经递质系统的变化。
Development of tolerance to benzodiazepines. I. Changes in the systems of central nervous system neurotransmitters during long-term administration of nitrazepam.
作者信息
Nowakowska E, Chodera A, Szczawińska K, Cenajek D
出版信息
Acta Physiol Pol. 1983 May-Jun;34(3):345-51.
PMID:6202092
Abstract
A purpose of the study was determination of the relationships between the brain levels of neuro-mediators: noradrenaline (NA), dopamine (DA), 5-hydroxytryptamine (5-HT) and gamma-aminobutyric acid (GABA) and the development of tolerance to the sedative and anticonvulsive action of Nitrazepam. It was found that during tolerance development the GABA level increased in the cerebral tissue and changes appeared in the activity state of the serotoninergic system.
摘要
该研究的目的是确定神经递质
去甲肾上腺素（NA）、多巴胺（DA）、5-羟色胺（5-HT）和γ-氨基丁酸（GABA）的脑内水平与硝西泮镇静和抗惊厥作用耐受性发展之间的关系。研究发现，在耐受性发展过程中，脑组织中的GABA水平升高，并且血清素能系统的活性状态出现变化。
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