Herman Z S, Jez W, Siemion I Z, Nawrocka E
Acta Physiol Pol. 1984 Sep-Dec;35(5-6):442-6.
The aim of this paper was to study the interaction between neurotensin and both enkephalins or its synthetic analogue D-Ala2-metenkephalinamide, or tuftsin, on the antinonciceptive effect of these peptides in mice after intracisternal injection. Antinociception was measured by the hot-plate method. It was shown that neurotensin antagonized evidently the antinociceptive effect of enkephalins and their analogue. On the contrary, neurotensin and tuftsin were agonists in induction of analgesia. It is concluded that neurotensin modulates in an opposite way the function of the enkephalinergic neurons and the central action of tuftsin.
本文旨在研究在小鼠脑池内注射后，神经降压素与脑啡肽或其合成类似物D - 丙氨酸2 - 甲硫脑啡肽酰胺，或促吞噬素之间的相互作用，以及这些肽的抗伤害感受作用。采用热板法测量抗伤害感受。结果表明，神经降压素明显拮抗脑啡肽及其类似物的抗伤害感受作用。相反，神经降压素和促吞噬素在诱导镇痛方面是激动剂。结论是，神经降压素以相反的方式调节脑啡肽能神经元的功能和促吞噬素的中枢作用。
