Nicolaides E D, Lunney E A, Kaltenbronn J S, Wiley J N, Downs D A
Int J Pept Protein Res. 1985 Apr;25(4):435-41. doi: 10.1111/j.1399-3011.1985.tb02198.x.
Several small peptides related to neurotensin (NT) and tuftsin were synthesized and tested for analgesic activity against acetic acid induced writhing in mice. None of the peptides approached the activity shown by NT or NT hexapeptide. Tuftsin itself was found to be weakly active. An isosteric dipeptide related to a cobra venom peptide was found to have considerable anti-writhing activity at a high intracerebroventricular dose.
合成了几种与神经降压素（NT）和促吞噬素相关的小肽，并测试了它们对乙酸诱导的小鼠扭体反应的镇痛活性。这些肽均未达到NT或NT六肽所显示的活性。发现促吞噬素本身活性较弱。一种与眼镜蛇毒肽相关的等排二肽在高脑室内剂量时具有相当大的抗扭体活性。
