Further studies on the properties of bile acids. I. Bile acid-induced changes of the action of drugs acting on the autonomic nervous system on the heart and blood vessels.

The action of certain drugs on the autonomic system was studied under the influence of bile acids: 3,12-dihydroxycholanic acid (deoxycholic), 3,7,12-trihydroxycholanic acid (cholic), and 3,7,12-triketocholanic acid (dehydrocholic). The experiments were carried out on rat heart in vivo and on isolated rat vessel preparation. It was shown that bile acids reduced the stimulating effect of isoprenaline on rat heart and the relaxing effect on the blood vessels. An inversion of the effects of adrenaline and noradrenaline on the rat heart was observed, and an enhancement of the vasoconstrictor effect of these substances. Under the conditions of this experiment an inversion was noted of the action of acetylcholine on the heart and blood vessels.