Rubial A, Alvarez Moro F J, Comet R, Bodi R, Lafuerza A, Domenech-Torné F M, Salvador L
Rev Esp Oncol. 1984;31(3):415-20.
Creatine kinase B (CK-B) was evaluated as a tumor marker by radioimmunoassay determination of the isoenzyme in 518 persons (control group, malignant tumors, and several other diseases). Amounts higher than 8 ng/ml (upper normal limit) was observed in 12.6 per 100 of the digestive tumors, 6.1 per 100 of the mammary tumors, 37.7 per 100 of the respiratory tumors, and 22.2 per 100 of the prostatic tumors. A relation exists between CK-B and sigmoid flexure, liver, pancreas and esophagus tumors, between CK-B and acid phosphatase in prostate tumors, and between CK-B and evolution of digestive tumor. The determination of CK-B is useful in the case of tumors lacking known tumor markers, and also as a complementary sign in the diagnosis and evolution of sigmoid flexure and prostate neoplasms.
通过放射免疫分析法对518人（对照组、恶性肿瘤患者及其他几种疾病患者）的肌酸激酶B（CK - B）同工酶进行测定，以此评估其作为肿瘤标志物的情况。在每100例消化肿瘤患者中，有12.6例CK - B含量高于8 ng/ml（正常上限）；每100例乳腺肿瘤患者中有6.1例；每100例呼吸道肿瘤患者中有37.7例；每100例前列腺肿瘤患者中有22.2例。CK - B与乙状结肠、肝脏、胰腺和食管肿瘤之间存在关联，在前列腺肿瘤中CK - B与酸性磷酸酶之间存在关联，且CK - B与消化肿瘤的进展有关。对于缺乏已知肿瘤标志物的肿瘤，CK - B的测定是有用的，并且在乙状结肠和前列腺肿瘤的诊断及病情进展中也可作为一项补充指标。
