Bouma W H, Mulder J H, Hop W C
Clin Exp Metastasis. 1983 Jul-Sep;1(3):205-12. doi: 10.1007/BF00736404.
An experimental model has been developed in which the effects of a pathological fracture and intramedullary nailing on metastatic spread have been investigated. The endpoint used was the production of lung metastases in rats inoculated intracortically with a rhabdomyosarcoma. We have found that a pathological fracture markedly increases the incidence of lung metastases and that intramedullary nailing, by decreasing the incidence of fractures, decreases the incidence of lung metastases. The surgical procedure itself does not increase the incidence significantly. It is concluded that in metastatic disease prophylactic nailing of an impending pathological fracture is the treatment of choice.
已建立一种实验模型，其中研究了病理性骨折和髓内钉固定对转移扩散的影响。所使用的终点指标是给大鼠皮质内接种横纹肌肉瘤后肺转移瘤的产生情况。我们发现病理性骨折显著增加肺转移的发生率，而髓内钉固定通过降低骨折发生率来降低肺转移的发生率。手术操作本身并不会显著增加发生率。得出的结论是，在转移性疾病中，对即将发生的病理性骨折进行预防性钉固定是首选治疗方法。
