Zoetmulder F A, Zwaveling A
Clin Exp Metastasis. 1983 Oct-Dec;1(4):381-90. doi: 10.1007/BF00121200.
A metastasizing tumour model in which a non-immunogenic tumor (Lewis lung carcinoma) is implanted in the caecum of syngeneic mice, is described. The most interesting property of this model is the formation of spontaneous hepatic and transperitoneal metastases. Resection of the caecum tumor 14 days after implantation leaves micrometastases in liver, peritoneum and lungs. This gives the opportunity for the study of adjuvant therapy. Adjuvant chemotherapy with cyclophosphamide cured a significant percentage of animals with micrometastases in liver and peritoneum. Cyclophosphamide therapy had no effect on micrometastases in liver and peritoneum when the primary tumor was left in place. This finding underlines the importance of aggressive treatment of the primary tumor before adjuvant chemotherapy can be effective in colorectal cancer.
本文描述了一种转移瘤模型，该模型是将一种非免疫原性肿瘤（Lewis肺癌）植入同基因小鼠的盲肠中。该模型最有趣的特性是会自发形成肝转移和经腹膜转移。植入后14天切除盲肠肿瘤，会在肝脏、腹膜和肺部留下微转移灶。这为辅助治疗的研究提供了机会。用环磷酰胺进行辅助化疗可使相当比例的肝脏和腹膜有微转移灶的动物得到治愈。当原位保留原发肿瘤时，环磷酰胺治疗对肝脏和腹膜的微转移灶没有影响。这一发现强调了在辅助化疗对结直肠癌有效之前，积极治疗原发肿瘤的重要性。
