Minamino N, Kangawa K, Matsuo H
Biochem Biophys Res Commun. 1984 Jul 31;122(2):542-9. doi: 10.1016/s0006-291x(84)80067-4.
A novel neurotensin-like peptide, designated neuromedin N, has been isolated from porcine spinal cord by using a bioassay for a stimulant effect on guinea pig ileum. By microsequencing, the amino acid sequence of the peptide has been determined to be Lys-Ile-Pro-Tyr-Ile-Leu, which is found to be quite homologous to the COOH-terminal sequence of neurotensin. This structure has been confirmed by synthesis. Neuromedin N exhibits a contractile activity on guinea pig ileum and induces a hypotensive response in the rat similar to that with neurotensin. These findings suggest that neuromedin N may be a new neuromediator or hormone with a specific spectrum of biological activity.
一种新的神经降压素样肽，命名为神经介素N，已通过对豚鼠回肠有刺激作用的生物测定法从猪脊髓中分离出来。通过微量测序，已确定该肽的氨基酸序列为Lys-Ile-Pro-Tyr-Ile-Leu，发现其与神经降压素的羧基末端序列非常同源。该结构已通过合成得到证实。神经介素N对豚鼠回肠表现出收缩活性，并在大鼠中诱导出与神经降压素相似的降压反应。这些发现表明神经介素N可能是一种具有特定生物活性谱的新神经介质或激素。
