Fusi F, Piazzesi G, Amerini S, Mugelli A, Livi S
J Pharmacol Methods. 1984 Mar;11(1):61-6. doi: 10.1016/0160-5402(84)90053-6.
A microcomputer system for automated analysis of action potentials recorded from cardiac Purkinje fibers is described. The system is based upon a DMD 800 microcomputer built around a Z80 microprocessor. Two different sampling intervals are used for analog-to-digital conversion of action potential recorded from driven fibers. The following parameters can be obtained on-line: action potential amplitude; overshoot; maximum diastolic potential; action potential duration measured both at -60 mV and at 90% of complete repolarization; and maximum rate of rise of the upstroke. The digitized form of five consecutive action potentials can be stored on a floppy disk. The automated system eliminates hand measurements; the on-line analysis of the action potentials during pharmacological interventions allows a rapid appreciation of drug effects.
本文描述了一种用于自动分析从心脏浦肯野纤维记录的动作电位的微机系统。该系统基于围绕Z80微处理器构建的DMD 800微机。对于从驱动纤维记录的动作电位的模数转换，使用了两种不同的采样间隔。可以在线获得以下参数：动作电位幅度；超射；最大舒张电位；在-60 mV和完全复极化的90%时测量的动作电位持续时间；以及上升支的最大上升速率。五个连续动作电位的数字化形式可以存储在软盘上。该自动化系统消除了手工测量；在药物干预期间对动作电位进行在线分析可快速评估药物效果。
