A spontaneous transplantable lymphosarcoma of the Syrian golden hamster (Mesocricetus auratus): Experimental induction of metastases after subcutaneous and intravenous inoculation.

A spontaneously occurring lymphosarcoma of the Syrian golden hamster was both subcutaneously and intravenously inoculated into 300 female and male animals each. Tumor growth was observed at a 100% rate. Using both types of inoculations, metastases occurred in 50% of the inoculated animals, preferentially in lungs, liver, pancreatic lymph nodes, spleen and kidney. The participation of different lymph node groups was more frequent after subcutaneous application. The transplantable tumor described might serve as a mode for additional studies on experimentally induced metastasis.