Leclere J, Bene M C, Duprez A, Faure G, Thomas J L, Vignaud J M, Burlet C
J Clin Endocrinol Metab. 1984 Jul;59(1):175-7. doi: 10.1210/jcem-59-1-175.
Thyroid tissue from five patients with hyperthyroidism due to Graves' disease was transplanted into nu/nu mice (2 to 4 mice per thyroid) in order to assess whether the tissues would remain hyperfunctional. Before surgery, the patients received only propranolol and iodine for ten days. Transplants were removed from the mice after 10, 20, 30 or 57 days, and compared to the initial tissue, as well as toxic nodules from two patients and thyroid tissue from two normal subjects grafted similarly. All transplants survived, as proven by histology and autohistoradiography with 131I uptake, while all signs of hyperfunction and dysimmunity disappeared. Conversely, both transplanted toxic nodules remained hyperfunctional. These results indicate that, in spite of the in situ presence of most factors of auto-immune reactions, thyroid tissue from patients with Graves' disease is not autonomous and depends on the extra-thyroid environment.
为了评估来自五名格雷夫斯病所致甲状腺功能亢进患者的甲状腺组织是否会保持功能亢进，将其移植到无胸腺裸鼠体内（每个甲状腺移植到2至4只小鼠）。手术前，患者仅接受普萘洛尔和碘治疗十天。在10、20、30或57天后从小鼠体内取出移植组织，并与初始组织、两名患者的毒性结节以及两名正常受试者同样移植的甲状腺组织进行比较。通过组织学和131I摄取的自动放射自显影证明，所有移植组织均存活，而所有功能亢进和免疫失调的迹象均消失。相反，两个移植的毒性结节仍保持功能亢进。这些结果表明，尽管自身免疫反应的大多数因素在原位存在，但格雷夫斯病患者的甲状腺组织并非自主的，而是依赖于甲状腺外环境。
