Vignaud J M, Duprez A, Bene M C, Leclere J, Faure G, Danchin N, Burlet C
Am J Pathol. 1984 Dec;117(3):355-9.
This study analyzes the outcome of human normal and hyperfunctioning thyroid tissue transplanted to the nude mouse. Thyroid fragments from 7 patients with Graves' disease were transplanted to nude mice (nu/nu). Before surgery, the patients had been treated with propranolol and iodine; none had received antithyroid therapy. The transplants were removed on the 12th day following transplantation and were studied by light microscopy and autohistoradiography. At this time, all immunologic disorders found on the operative samples had disappeared, and the tissue had lost its hyperfunctioning characteristics. In contrast, transplants from toxic adenoma remained hyperfunctioning, with elevated serum T3 and T4 levels. Similarly, transplants from normal thyroid tissue remained unchanged, and serum T3 and T4 levels remained within the normal range, as if under the influence of the hypothalamic and pituitary regulation of the mice. These findings emphasize the role of the extrathyroid immunologic environment in the regulation of Graves' disease, whereas toxic adenoma remains autonomous.
本研究分析了移植到裸鼠体内的人类正常及功能亢进甲状腺组织的结果。将7例格雷夫斯病患者的甲状腺碎片移植到裸鼠（nu/nu）体内。手术前，患者接受了普萘洛尔和碘治疗；均未接受抗甲状腺治疗。移植后第12天取出移植物，进行光学显微镜检查和放射自显影研究。此时，手术样本上发现的所有免疫紊乱均已消失，组织已失去其功能亢进的特征。相比之下，毒性腺瘤的移植物仍保持功能亢进，血清T3和T4水平升高。同样，正常甲状腺组织的移植物保持不变，血清T3和T4水平仍在正常范围内，就好像受到小鼠下丘脑和垂体调节的影响。这些发现强调了甲状腺外免疫环境在格雷夫斯病调节中的作用，而毒性腺瘤则保持自主性。
