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[亲属过敏发生率对其后代婴儿惊厥和癫痫发病风险水平的影响]

[Effect of the incidence of allergies among relatives on the risk level for development of infantile convulsions and epilepsy in their progeny].

作者信息

Utin A V

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1978;78(4):580-2.

PMID:654732
Abstract

A clinico-genealogical study revealed an increased (in 2--3 times) frequency of allergies in epileptic patients and their close relatives (291 families) in comparison with a general population (118 families). Risk for appearance of epilepsy and children's convulsions among the sibs of the probands with parental allergic loading occurred to be 2 times higher than without it. It is established that parental allergic loading and its degree is one of a family-constitutional risk factors that significantly raises the frequency of a phenotypical manifestation of hereditary predisposition to epilepsy and children's convulsions.

摘要

一项临床系谱研究表明,与普通人群(118个家庭)相比,癫痫患者及其近亲(291个家庭)中过敏症的发生率增加了(2至3倍)。在先证者的同胞中,父母有过敏负荷时出现癫痫和儿童惊厥的风险比没有过敏负荷时高2倍。已确定父母的过敏负荷及其程度是家族体质性风险因素之一,可显著提高癫痫和儿童惊厥遗传易感性表型表现的发生率。

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