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Enzymatic synthesis of the penicillin and cephalosporin nuclei from an acyclic peptide containing carboxymethylcysteine.

作者信息

Bowers R J, Jensen S E, Lyubechansky L, Westlake D W, Wolfe S

出版信息

Biochem Biophys Res Commun. 1984 Apr 30;120(2):607-13. doi: 10.1016/0006-291x(84)91298-1.

DOI:10.1016/0006-291x(84)91298-1
PMID:6547336
Abstract

The tripeptide delta-(L- carboxymethylcysteinyl )-L-cysteinyl-D-valine (L-CMC-CV) is converted sequentially into the CMC analog of isopenicillin N, the CMC analog of penicillin N, and the CMC analog of desacetoxycephalosporin C by, respectively, isopenicillin N synthetase, isopenicillin N epimerase, and desacetoxycephalosporin C synthetase, all isolated from the beta-lactam producing prokaryote Streptomyces clavuligerus.

摘要

相似文献

1
Enzymatic synthesis of the penicillin and cephalosporin nuclei from an acyclic peptide containing carboxymethylcysteine.
Biochem Biophys Res Commun. 1984 Apr 30;120(2):607-13. doi: 10.1016/0006-291x(84)91298-1.
2
Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins.青霉素和头孢菌素生物合成相关基因的表达及酶的加工过程。
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Appl Microbiol Biotechnol. 1998 Jul;50(1):1-15. doi: 10.1007/s002530051249.
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Ammonium repression of cephalosporin production by Streptomyces clavuligerus.
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Relationship between nitrogen assimilation and cephalosporin synthesis in Streptomyces clavuligerus.棒状链霉菌中氮同化与头孢菌素合成之间的关系。
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Enzymatic conversion of the unnatural tripeptide delta-(D-alpha-aminoadipyl)-L-cysteinyl-D-valine to beta-lactam antibiotics.非天然三肽δ-（D-α-氨基己二酰基）-L-半胱氨酰-D-缬氨酸向β-内酰胺抗生素的酶促转化
J Antibiot (Tokyo). 1984 Sep;37(9):1044-8. doi: 10.7164/antibiotics.37.1044.
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Isopenicillin N synthetase of Penicillium chrysogenum, an enzyme that converts delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to isopenicillin N.产黄青霉的异青霉素N合成酶，一种将δ-（L-α-氨基己二酰基）-L-半胱氨酰-D-缬氨酸转化为异青霉素N的酶。
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Bioorg Med Chem. 1993 Jul;1(1):1-17. doi: 10.1016/s0968-0896(00)82098-2.

引用本文的文献

1
Biochemical studies on the activity of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus.来自棒状链霉菌的δ-（L-α-氨基己二酰基）-L-半胱氨酰-D-缬氨酸合成酶活性的生化研究。
Biochem J. 1992 May 1;283 ( Pt 3)(Pt 3):691-8. doi: 10.1042/bj2830691.