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The enzymes involved in biosynthesis of penicillin and cephalosporin; their structure and function.

作者信息

Cooper R D

机构信息

Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285.

出版信息

Bioorg Med Chem. 1993 Jul;1(1):1-17. doi: 10.1016/s0968-0896(00)82098-2.

DOI:10.1016/s0968-0896(00)82098-2
PMID:8081833
Abstract

The biosynthetic pathway resulting in the penicillins and cephalosporins contains two Fe2+ oxidase enzymes which are responsible for the conversion of alpha-aminoadipoyl-L-cysteinyl-D-valine into isopenicillin N and penicillin N into deacetoxycephalosporin C. We will discuss the studies delineating the ligand binding of these enzymes and present a possible secondary structure.

摘要

相似文献

1
The enzymes involved in biosynthesis of penicillin and cephalosporin; their structure and function.
Bioorg Med Chem. 1993 Jul;1(1):1-17. doi: 10.1016/s0968-0896(00)82098-2.
2
Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins.青霉素和头孢菌素生物合成相关基因的表达及酶的加工过程。
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3
Molecular biology of penicillin and cephalosporin biosynthesis.青霉素和头孢菌素生物合成的分子生物学
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4
Enzymes involved in penicillin, cephalosporin and cephamycin biosynthesis.
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5
Organization and expression in Pseudomonas putida of the gene cluster involved in cephalosporin biosynthesis from Lysobacter lactamgenus YK90.来自产内酰胺溶杆菌属YK90的头孢菌素生物合成相关基因簇在恶臭假单胞菌中的组织与表达
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6
Enzymatic synthesis of the penicillin and cephalosporin nuclei from an acyclic peptide containing carboxymethylcysteine.
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New aspects of genes and enzymes for beta-lactam antibiotic biosynthesis.β-内酰胺抗生素生物合成中基因与酶的新进展。
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Studies on the ring-cyclization and ring-expansion enzymes of beta-lactam biosynthesis in Cephalosporium acremonium.顶头孢霉中β-内酰胺生物合成的环化和扩环酶研究。
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9
Enzymatic conversion of the unnatural tripeptide delta-(D-alpha-aminoadipyl)-L-cysteinyl-D-valine to beta-lactam antibiotics.非天然三肽δ-（D-α-氨基己二酰基）-L-半胱氨酰-D-缬氨酸向β-内酰胺抗生素的酶促转化
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10
Recent advances in the structure and function of isopenicillin N synthase.
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Reconstitution of TCA cycle with DAOCS to engineer Escherichia coli into an efficient whole cell catalyst of penicillin G.用二氨基二环辛烷重建三羧酸循环以将大肠杆菌工程改造成为青霉素G的高效全细胞催化剂。
Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9855-9. doi: 10.1073/pnas.1502866112. Epub 2015 Jul 27.
6
Iterative combinatorial mutagenesis as an effective strategy for generation of deacetoxycephalosporin C synthase with improved activity toward penicillin G.迭代组合突变作为一种有效的策略，用于生成对青霉素 G 具有更高活性的去乙酰氧基头孢菌素 C 合酶。
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