α,β-二丙烯酰氧基丙酸，一种工业丙烯酸中的致敏杂质。

alpha, beta-Diacryloxypropionic acid, a sensitizing impurity in commercial acrylic acid.

作者信息

Waegemaekers T H, van der Walle H B

出版信息

Derm Beruf Umwelt. 1984;32(2):55-8.

Abstract

In samples of commercial acrylic acid a strongly contact sensitizing constituent was discovered by application of Freund's Complete Adjuvant Test in guinea pigs. The skin reactions were due to the presence of varying quantities of alpha,beta- diacryloxypropionic acid (DAPA), which was identified after methylation. The commercial product is an example of a composition that defies gas-chromatographic quality-control: Under the circumstances of this analysis the secondary product that is formed during the synthesis of acrylic acid is so unstable that it does not pass polar liquid phases. Distilled acrylic acid does not contain the sensitizing acid.

摘要

在商用丙烯酸样品中，通过在豚鼠身上应用弗氏完全佐剂试验发现了一种强接触致敏成分。皮肤反应是由于存在不同量的α,β - 二丙烯酰氧基丙酸（DAPA），该成分在甲基化后得以鉴定。该商业产品是一种难以通过气相色谱进行质量控制的组合物实例：在这种分析情况下，丙烯酸合成过程中形成的副产物非常不稳定，以至于无法通过极性液相。蒸馏后的丙烯酸不含致敏酸。