14种单（甲基）丙烯酸酯在豚鼠中的致敏潜力
Sensitizing potential of 14 mono (meth) acrylates in the guinea pig.
作者信息
van der Walle H B, Klecak G, Geleick H, Bensink T
出版信息
Contact Dermatitis. 1982 Jul;8(4):223-35. doi: 10.1111/j.1600-0536.1982.tb04204.x.
The aim of this study was to investigate differences in the sensitizing potential of 14 mono(meth)acrylates, when tested by the guinea pig maximization test (GPMT) and Freund's complete adjuvant test (FCAT) with an identical, intradermal induction concentration. A new grading classification of the sensitization potential is proposed. Mono(meth)acrylates show a wide range of sensitizing potential. Compared with other (meth)acrylates, methyl methacrylate is a moderate sensitizer. Attention was paid to concomitant sensitization of additives. In 9 of 16 FCATs, concomitant sensitization occurred to the inhibitors hydroquinone and p-methoxyphenol.
本研究的目的是在相同皮内诱导浓度下，通过豚鼠最大化试验（GPMT）和弗氏完全佐剂试验（FCAT），研究14种单（甲基）丙烯酸酯致敏潜力的差异。提出了一种新的致敏潜力分级分类方法。单（甲基）丙烯酸酯显示出广泛的致敏潜力。与其他（甲基）丙烯酸酯相比，甲基丙烯酸甲酯是一种中度致敏剂。研究关注了添加剂的伴随致敏情况。在16次FCAT试验中的9次中，对抑制剂对苯二酚和对甲氧基苯酚出现了伴随致敏现象。
Zotero 插件