Willey J C, Lechner J F, Harris C C
Exp Cell Res. 1984 Jul;153(1):245-8. doi: 10.1016/0014-4827(84)90466-x.
Bombesin and the C-terminal portion of gastrin-releasing peptide (GRP14-27) each increase clonal growth rate and colony-forming efficiency of normal human bronchial epithelial cells. These effects occur in the presence or absence of an optimal concentration (5 ng/ml) of epidermal growth factor (EGF). In contrast to EGF bombesin and GRP14-27 do not stimulate cell migration. Thus, bombesin and the C-terminal fragment of gastrin-releasing peptide represent a new class of peptides mitogenic for normal human epithelial cells.
蛙皮素和胃泌素释放肽的C末端部分（GRP14 - 27）均可提高正常人支气管上皮细胞的克隆生长速率和集落形成效率。无论是否存在最佳浓度（5 ng/ml）的表皮生长因子（EGF），这些作用都会发生。与EGF不同，蛙皮素和GRP14 - 27不会刺激细胞迁移。因此，蛙皮素和胃泌素释放肽的C末端片段代表了一类对正常人上皮细胞有促有丝分裂作用的新型肽。
