Rambeck W A, Weiser H, Zucker H
Int J Vitam Nutr Res. 1984;54(1):25-34.
For the first time, the biological activity of the newly synthesized glycosides of vitamin D3 and of 1 alpha(OH)D3 has been studied in rats, chickens, and Japanese quails. Glucosidation did not reduce the activity of vitamin D3. In chickens, vitamin D3 glucoside has an activity of 90% to 95% as compared to the aglycon. In rats vitamin D3 glucoside is equally active when given by intravenous or oral route. Glycosides of 1 alpha (OH)D3, however, show a lower activity in rats, chickens, and quails. 1 alpha (OH)D3 glucoside has about 10% activity of the free 1 alpha (OH)D3, while 1 alpha (OH)D3 cellobioside is without any activity in chickens. 1 alpha (OH)D3 glucoside might be of interest, due to its broader therapeutical dosage range.
首次在大鼠、鸡和日本鹌鹑身上研究了新合成的维生素D3糖苷和1α(OH)D3糖苷的生物活性。葡萄糖苷化并未降低维生素D3的活性。在鸡身上，维生素D3糖苷的活性与苷元相比为90%至95%。在大鼠中，维生素D3糖苷经静脉或口服给药时活性相同。然而，1α(OH)D3的糖苷在大鼠、鸡和鹌鹑中表现出较低的活性。1α(OH)D3葡萄糖苷的活性约为游离1α(OH)D3的10%，而1α(OH)D3纤维二糖苷在鸡中没有任何活性。1α(OH)D3葡萄糖苷因其更宽的治疗剂量范围可能会受到关注。
