曲安奈德的化学修饰以改善脂质体包封率。
Chemical modification of triamcinolone acetonide to improve liposomal encapsulation.
作者信息
Goundalkar A, Mezei M
出版信息
J Pharm Sci. 1984 Jun;73(6):834-5. doi: 10.1002/jps.2600730634.
PMID:6547482
Abstract
The 21-palmitate of triamcinolone acetonide was synthesized to aid in the liposomal encapsulation of the drug. Encapsulation efficiency of triamcinolone acetonide-21-palmitate was 85%, compared with 5% for the parent drug.
摘要
合成曲安奈德的21-棕榈酸酯以辅助该药物的脂质体包封。曲安奈德-21-棕榈酸酯的包封效率为85%，而母体药物的包封效率为5%。
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