Girchev R, Vrabchev N
Acta Physiol Pharmacol Bulg. 1984;10(1):38-47.
The subject of the present study is to compare various diuretic effects through a number of criteria included in a programme developed by us on the basis of an improved model of the method of W.P. Leary and A.J. Reyes for description of the dynamics of the renal excretory function. The effects compared were: of diuretics different in potency and duration of action; of different doses of one and the same diuretic; of different diuretics and placebo--0.9% solution of sodium chloride. The rate of excretion prior to the diuretic administration is graphically represented which enables the estimation of presence or absence of diuretic effect of the pharmacological substance applied. This also makes possible the evaluation of the specific effect of the diuretics with regard to different electrolytes which improves the approach when the diuretics are to be combined and helps their optimum dosage and distribution within time.
本研究的主题是通过我们根据W.P. Leary和A.J. Reyes方法改进模型开发的程序中包含的若干标准，比较各种利尿效果。所比较的效果包括：作用强度和持续时间不同的利尿剂的效果；同一利尿剂不同剂量的效果；不同利尿剂和安慰剂（0.9%氯化钠溶液）的效果。以图表形式呈现利尿剂给药前的排泄速率，这有助于评估所应用药理物质是否存在利尿作用。这也使得评估利尿剂对不同电解质的特定作用成为可能，从而在联合使用利尿剂时改进方法，并有助于其最佳剂量和时间分布。
