Collins A J, Notarianni L J, Ring E F, Seed M P
Ann Rheum Dis. 1984 Jun;43(3):411-5. doi: 10.1136/ard.43.3.411.
A topically applied rubifacient delivered by aerosol (Deep-Heat) was studied. After spray application to the forearms of volunteers, without massage, the erythema produced was measured by thermography and correlated with the concentration of 2 salicylate components of the mixture found in local and systemic venous blood. Maximum erythema occurred at about 30 minutes, while blood salicylate levels were maximal between 20 and 30 minutes after application. Methyl salicylate was absorbed before ethyl salicylate. Over the time period of the erythematous response oxygen levels in local venous blood were raised. Finally, platelets collected from venous blood draining from the sprayed site, when induced to clump by the addition of arachidonic acid in an aggregometer, showed increased resistance to clumping when compared with control cells. The mechanism of these observed phenomena and the mode of action of the constituents of Deep-Heat are discussed.
对一种通过气雾剂递送的局部用擦剂（Deep-Heat）进行了研究。在对志愿者的前臂进行喷雾应用后，不进行按摩，通过热成像测量产生的红斑，并将其与在局部和全身静脉血中发现的混合物的2种水杨酸盐成分的浓度相关联。最大红斑出现在约30分钟时，而血液水杨酸盐水平在应用后20至30分钟之间达到最大值。甲基水杨酸酯比乙基水杨酸酯先被吸收。在红斑反应的时间段内，局部静脉血中的氧水平升高。最后，从喷雾部位引流的静脉血中收集的血小板，当在聚集仪中通过添加花生四烯酸诱导聚集时，与对照细胞相比，显示出对聚集的抗性增加。讨论了这些观察到的现象的机制以及Deep-Heat成分的作用方式。
