Husztik E, Lázár G, Szabó E
Br J Exp Pathol. 1984 Jun;65(3):313-8.
Peliosis hepatis has been induced immunologically with anti-rat glomerular basal membrane rabbit serum in rats pre-sensitized with a rare earth metal complex, neodymium pyrocatechin disulphonate (NPD). This is the first experimental evidence that peliosis hepatis may develop as a result of an immunological process. It is noteworthy that in this experimental form of peliosis hepatis and in that observed earlier in rats treated with basic polyglutamic acid derivatives, severe defibrination was detected and, as in most human cases, not only the liver but other organs were also involved in the peliotic lesions. Since the rare earth metal compounds, among them the pyrocatechin disulphonate complex of neodymium, depress the reticulo-endothelial activity, a role of the reticulo-endothelial system in the pathogenesis of this experimental form of peliosis hepatis is suggested.
在了肝细胞已在预先用稀土金属络合物焦儿茶酚二磺酸钕（NPD）致敏的大鼠中，用抗大鼠肾小球基底膜兔血清通过免疫方式诱导肝紫癜。这是肝紫癜可能作为免疫过程结果而发生的首个实验证据。值得注意的是，在这种实验性肝紫癜形式以及早期在用碱性聚谷氨酸衍生物处理的大鼠中观察到的情况中，检测到严重的纤维蛋白原减少，并且与大多数人类病例一样，不仅肝脏，其他器官也参与了紫癜性病变。由于稀土金属化合物，其中包括钕的焦儿茶酚二磺酸络合物，会抑制网状内皮系统的活性，因此提示网状内皮系统在这种实验性肝紫癜发病机制中起作用。
