Seawright A A
Vet Hum Toxicol. 1984 Jun;26(3):208-13.
Peliosis hepatis can be produced predictably in cattle following regular oral dosing for several weeks with dried plant of various Pimelea spp which contain irritant diterpenoid daphnane esters such as simplexin . The condition is associated with a massive hypervolemia and cor pulmonale. Affected animals may recover after removal of the toxin from the diet. The mechanism of peliosis hepatis in man and other species is obscure, and the present model in the large domestic species could well be employed in investigations of the pathogenesis of this lesion. The condition appears to have its origin as a portal venular ectasia and can be regarded as a true phlebectatic peliosis hepatis. Blood volume measurements may be of value in forecasting the possible development of peliosis hepatis in humans, which may occur in association with regular long-term anabolic steroid therapy.
连续数周定期给牛口服各种含有刺激性二萜瑞香烷酯（如单辛素）的澳石南属植物干燥植株后，可诱发牛发生肝紫癜。这种情况与大量血容量过多和肺心病有关。从饮食中去除毒素后，患病动物可能会康复。人类和其他物种肝紫癜的发病机制尚不清楚，目前在大型家养动物中建立的这个模型很可能用于该病变发病机制的研究。这种情况似乎起源于门静脉小静脉扩张，可被视为真正的静脉扩张性肝紫癜。血容量测量对于预测人类可能发生的肝紫癜可能具有重要价值，肝紫癜可能与长期定期使用合成代谢类固醇治疗有关。
