伴有8号染色体长臂24区带异常的恶性淋巴瘤：从伯基特淋巴瘤到免疫母细胞淋巴瘤的形态学连续谱。

Malignant lymphomas with band 8q24 chromosome abnormality: a morphologic continuum extending from Burkitt's to immunoblastic lymphoma.

作者信息

Sigaux F, Berger R, Bernheim A, Valensi F, Daniel M T, Flandrin G

出版信息

Br J Haematol. 1984 Jul;57(3):393-405. doi: 10.1111/j.1365-2141.1984.tb02913.x.

DOI:10.1111/j.1365-2141.1984.tb02913.x

Abstract

Chromosome abnormality involving band 8q24 is present in the malignant cells in virtually all 'Burkitt's' type malignancies. t(8;14)(q24;q32) translocations have nevertheless been found in certain cases of malignant lymphomas (ML) described as 'small non-cleaved non-Burkitt', 'immunoblastic' or 'histiocytic'. With a view to comparing objectively the histological picture of such lymphomas, we undertook morphometric analysis of seven cases of diffuse ML classed as 'Burkitt's' (three cases), 'immunoblastic' (two cases), 'small non-cleaved non-Burkitt' (one case) and 'large-cell lymphoma' (one case), all exhibiting band 8q24 rearrangement arising from various translocations. Our study substantiates the view that the histologic picture of MLs with 8q24 anomaly fits into a morphological continuum containing 'Burkitt's', 'small non-cleaved non-Burkitt' and 'immunoblastic' lymphomas.

摘要

几乎所有“伯基特氏”型恶性肿瘤的恶性细胞中都存在涉及8号染色体q24带的染色体异常。然而，在某些被描述为“小无裂非伯基特氏”、“免疫母细胞性”或“组织细胞性”的恶性淋巴瘤（ML）病例中发现了t(8;14)(q24;q32)易位。为了客观比较此类淋巴瘤的组织学表现，我们对7例弥漫性ML进行了形态计量分析，这些病例被分类为“伯基特氏”（3例）、“免疫母细胞性”（2例）、“小无裂非伯基特氏”（1例）和“大细胞淋巴瘤”（1例），所有病例均表现出由各种易位引起的8q24带重排。我们的研究证实了这样一种观点，即具有8q24异常的ML的组织学表现符合一个形态学连续谱，其中包括“伯基特氏”、“小无裂非伯基特氏”和“免疫母细胞性”淋巴瘤。